Work

Pyrosequencing To Detect Mutations in FKS1 That Confer Reduced Echinocandin Susceptibility in Candida albicans

Year: 2008

Type: article

Abstract: Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans. These methods were in complete agreement for 10 of 12 clinical isolates with elevated echinocandin MICs, supporting the potential feasibility of pyrosequencing to detect mutations within diploid fungi.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00959-08

Authors: Nathan P. Wiederhold, Jodi L. Grabinski, Guillermo Garcia-Effron, David S. Perlin, Samuel A. Lee

Institutions: The University of Texas at San Antonio Health Science Center, The University of Texas at Austin, Rutgers New Jersey Medical School, University of New Mexico, University of New Mexico Health Sciences Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases