Association of Variation at the ABO Locus With Circulating Levels of Soluble Intercellular Adhesion Molecule-1, Soluble P-selectin, and Soluble E-selectin
Year: 2011
Type: article
Abstract: BACKGROUND: Circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at the ABO locus. To evaluate these associations and the effect sizes, we performed a meta-analysis with new and previous reported data for polymorphism rs579459. METHODS AND RESULTS: Compared with major allele homozygotes, heterozygotes and minor allele homozygotes had 4.6% (95% CI, 3.4%-5.8%, P=7.3 × 10(-14)) and 7.2% (95% CI, 4.7%-9.7%, P=1.5 × 10(-8)), respectively, lower soluble intercellular adhesion molecule-1 levels (n=33 671). An allele dose-dependent association also was observed for soluble P-selectin (n=4921) with heterozygotes and minor allele homozygotes having 11.5% (95% CI, 7.2%-15.8%, P=1.7 × 10(-7)) and 18.6% (95% CI, 9.1%-28.1%, P=1.2 × 10(-4)), respectively, lower levels than in major allele homozygotes. A larger effect size, again consistent with an additive genetic model, was seen for soluble E-selectin (n=2860) whose level was 25.6% (95% CI, 19.0%-32.2%, P=2.1 × 10(-14)) lower in heterozygotes and 43.3% (95% CI, 36.9%-49.3%, P=4.3 × 10(-42)) lower in minor allele homozygotes than in major allele homozygotes. CONCLUSIONS: The data support the association of variation at the ABO locus with soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin levels.
Authors: Stefan Kiechl, Guillaume Paré, Maja Barbalic, Lu Qi, Josée Dupuis, Abbas Dehghan, Joshua C. Bis, Ross C. Laxton, Qingzhong Xiao, Enzo Bonora, Johann Willeit, Qingbo Xu, Jacqueline C.M. Witteman, Daniel Chasman, Russell P. Tracy, Christie M. Ballantyne, Paul M. Ridker, Emelia J. Benjamin, Shu Ye
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Donald W. Reynolds Foundation, British Heart Foundation, National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Center for Research Resources
Awards: G1052397333, G1135917780, G1243299691, G1527150935, G1528515809, G1691174148, G173303992, G1941623656, G229684361, Institute for Clinical and Translational Research (UL1), G250621538, G2818629771, G3114902838, Pharmacogenomics and Risk of Cardiovascular Disease, G3410686264, G3462919067, G36937976, GWA for Gene-Environment Interaction Effects Influencing CHD, Patterns of Health Care Use, Treatment & Outcomes in Atrial Fibrillation: PATH-AF, G395403786, A study of matrix metalloproteinase-8 in stem/progenitor cell mobilisation and recruitment to atherosclerotic lesions, Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study, G457330776, Pharmacogenomics and Risk of Cardiovascular Disease, G5164707915, INFLAMMATION: CORRELATES AND PROGNOSIS IN FRAMINGHAM, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G552178769, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G558986044, G567847597, Framingham: Inflammation, Genes & Cardiovascular Disease, The Framingham Heart Study, G6548750934, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, G6885760426, Women's Health Study: Continued Follow-up, Risk prediction of atrial fibrillation: clinical, biological and genetic markers, Regulation of matrix metalloproteinase-14 expression by hypoxia-inducible transcription factor – implications in neovessel formation in atherosclerotic plaques, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal
OpenAlex ID: W2163084301