Swept source / Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit
Year: 2012
Type: article
Abstract: Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050 nm at 100 kHz axial scan rates using single mode fiber optics and a multiplexing approach. Unlike previously reported PS-OCT multiplexing schemes, the method uses a passive polarization delay unit and does not require active polarization modulating devices. This advance decreases system cost and avoids complex synchronization requirements. The polarization delay unit was implemented in the sample beam path in order to simultaneously illuminate the sample with two different polarization states. The orthogonal polarization components for the depth-multiplexed signals from the two input states were detected using dual balanced detection. PS-OCT images were computed using Jones calculus. 3D PS-OCT imaging was performed in the human and rat retina. In addition to standard OCT images, PS-OCT images were generated using contrast form birefringence and depolarization. Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images.
Source: Optics Express
DOI: 10.1364/oe.20.010229
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,270
Funders: Tufts Medical Center, Joslin Diabetes Center, Universität Wien, Medizinische Universität Wien, National Institutes of Health, National Heart, Lung, and Blood Institute, National Eye Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Air Force Office of Scientific Research
Awards: G1169916466, G1357245228, G1523888516, Guiding the Treatment of Anterior Eye Disease with Optical Coherence Tomography, Advanced Imaging for Glaucoma, Novel Optical Diagnostics with Optical Coherence Tomography, Role of the kallikrein-kinin system in diabetic retinopathy, G5304285953, G5520316217, G593967775, Investigating the Early Embryonic Murine Heart Using Optical Coherence Tomography, G6461857139, Optical Biopsy Using Optical Coherence Tomography, Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology, G9000095117, Novel Glaucoma Diagnostics for Structure and Function.
OpenAlex ID: W2080057916