Work

Multicomponent Assembly Strategies for the Synthesis of Diverse Tetrahydroisoquinoline Scaffolds

Year: 2011

Type: article

Abstract: Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine.

Source: Organic Letters

DOI: 10.1021/ol201739u

Authors: Brett A. Granger, Kyosuke Kaneda, Stephen F. Martin

Institution: The University of Texas at Austin

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G150393960, G1649042011, Generating Diverse Pilot-Scale Libraries for Screening, Synthesis of Nitrogen Containing Natural Products