Genotypic Resistance Tests Sequences Reveal the Role of Marginalized Populations in HIV-1 Transmission in Switzerland
Year: 2016
Type: article
Abstract: Targeting hard-to-reach/marginalized populations is essential for preventing HIV-transmission. A unique opportunity to identify such populations in Switzerland is provided by a database of all genotypic-resistance-tests from Switzerland, including both sequences from the Swiss HIV Cohort Study (SHCS) and non-cohort sequences. A phylogenetic tree was built using 11,127 SHCS and 2,875 Swiss non-SHCS sequences. Demographics were imputed for non-SHCS patients using a phylogenetic proximity approach. Factors associated with non-cohort outbreaks were determined using logistic regression. Non-B subtype (univariable odds-ratio (OR): 1.9; 95% confidence interval (CI): 1.8-2.1), female gender (OR: 1.6; 95% CI: 1.4-1.7), black ethnicity (OR: 1.9; 95% CI: 1.7-2.1) and heterosexual transmission group (OR:1.8; 95% CI: 1.6-2.0), were all associated with underrepresentation in the SHCS. We found 344 purely non-SHCS transmission clusters, however, these outbreaks were small (median 2, maximum 7 patients) with a strong overlap with the SHCS'. 65% of non-SHCS sequences were part of clusters composed of >= 50% SHCS sequences. Our data suggests that marginalized-populations are underrepresented in the SHCS. However, the limited size of outbreaks among non-SHCS patients in-care implies that no major HIV outbreak in Switzerland was missed by the SHCS surveillance. This study demonstrates the potential of sequence data to assess and extend the scope of infectious-disease surveillance.
Source: Scientific Reports
DOI: 10.1038/srep27580
Authors: Mohaned Shilaih, Alex Marzel, Wan Lin Yang, Alexandra U. Scherrer, Jörg Schüpbach, Jürg Böni, Sabine Yerly, Hans H. Hirsch, Vincent Aubert, Matthias Cavassini, Thomas Klimkait, Pietro L. Vernazza, Enos Bernasconi, Hansjakob Furrer, Huldrych F. Günthard, Roger Kouyos, Swiss HIV Cohort Study, Manuel Battegay, Dominique Braun, Heiner Bucher, Claudine Burton-Jeangros, Alexandra Calmy, Günter Dollenmaier, Matthias Egger, Luigia Elzi, Jan Fehr, Jaque Fellay, Christoph Fux, Meri Gorgievski, David Haerry, Barbara Hasse, Matthias Hoffmann, Irene Hösli, Christian Kahlert, Laurent Kaiser, Olivia Keiser, Helen Kovari, Bruno Ledergerber, Gladys Martinetti, Begoña Martinez de Tejada, Catia Marzolini, Karin Metzner, Nicolas Müller, David Nadal, Dunja Nicca, Giuseppe Pantaleo, Andre Rauch, Stephan Regenass, Christoph Rudin, Franziska Schöni-Affolter, Patrick Schmid, Roberto Speck, Marcel Stöckle, Philip Tarr, Alexandra Trkola, Reiner Weber
Institutions: University of Zurich, University Hospital Zurich, University Hospital of Geneva, University of Basel, Centre Hospitalier Universitaire Vaudois, University Hospital of Basel, Kantonsspital St. Gallen, Ospedale regionale di Lugano, University of Bern, University Hospital of Bern, University of Geneva, École Polytechnique Fédérale de Lausanne, Kantonsspital Aarau, Kantonsspital Baselland, Ostschweizer Kinderspital, University Children's Hospital Zurich, University Children’s Hospital Basel
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1323383031, HIV-1 drug resistance in the swiss HIV cohort study: epidemiology and impact on the management of HIV infected patients, Using transmission networks for assessing and guiding prevention efforts in hiv, G2924732230, HIV-1 Transmission in Switzerland: Long term-molecular epidemiology and biological properties of transmitted viruses, G4104599821, Swiss HIV Cohort Study (SHCS), G6401315242, G7262634952, Combining molecular epidemiology approaches and mathematical models for the spread of HIV and its coinfections, G8586152943
OpenAlex ID: W2420144268