Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study
Year: 2016
Type: article
Study design: Observational Study
Abstract: Background. The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods. In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these SNPs in HIV-positive, white Swiss HIV Cohort Study participants. We included 103 individuals with a first, physician-validated LTF and 206 controls matched on gender, whose duration of observation and whose antiretroviral therapy start dates were similar using incidence density sampling. Analyses of nongenetic LTF risk factors were based on 158 cases and 788 controls. Results. A genetic risk score built from the 6 LTF-associated SNPs did not associate with LTF risk, in both models including and not including parental hip fracture history. The contribution of clinical LTF risk factors was limited in our dataset. Conclusions. Genetic LTF markers with a modest effect size in the general population do not improve fracture prediction in persons with HIV, in whom clinical LTF risk factors are prevalent in both cases and controls.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofw101
Authors: Thomas Junier, Margalida Rotger, Emmanuel Biver, Bruno Ledergerber, Catalina Barceló, Istvan Bartha, Helen Kovari, Patrick Schmid, Christoph Fux, Enos Bernasconi, Claudia Brun del Re, Rainer Weber, Jacques Fellay, Philip E. Tarr, The Swiss HIV Cohort Study, V Aubert, M Battegay, E Bernasconi, J Böni, DL Braun, HC Bucher, C Burton-Jeangros, A Calmy, M Cavassini, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, M Gorgievski, H Günthard, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, C Marzolini, K Metzner, N Müller, D Nadal, D Nicca, G Pantaleo, A Rauch, S Regenass, C Rudin, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, P Vernazza, R Weber, S Yerly
Institutions: SIB Swiss Institute of Bioinformatics, École Polytechnique Fédérale de Lausanne, Centre Hospitalier Universitaire Vaudois, University of Lausanne, University Hospital of Geneva, University of Zurich, University Hospital Zurich, Kantonsspital St. Gallen, University of Basel, Kantonsspital Aarau, Ospedale regionale di Lugano, University of Bern, University Hospital of Bern, Kantonsspital Baselland, Kantonsspital Baselland Standort Bruderholz
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
OpenAlex ID: W2439110334