Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages
Year: 2016
Type: article
Abstract: Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+ T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+ and CD8+ T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies.
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: Johns Hopkins University, National Institutes of Health, Center for AIDS Research, University of Washington, National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: Patient-Oriented Research and Mentorship in HIV and Non-Communicable Diseases, Institute for Clinical and Translational Research, INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERS, G2483435703, G3263515948, Analysis of HIV-1 in mucosal tissue in elite suppressors, Mechanisms of COPD Subphenotype Development, The Study of HIV Infection in the Etiology of Lung Disease (SHIELD), G7178514535, Predictors consequences and mechanisms of accelerated lung aging in HIV, Cellular and Molecular Medicine, G9000111512, AIDS Linked to the IntraVenous Experience (ALIVE) Study, The Johns Hopkins Center for AIDS Research (JHU CFAR), Multidisciplinary Training Program in Lung Disease
OpenAlex ID: W2530837323