Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus
Year: 2017
Type: article
Abstract: Consolidation of declarative memories requires hippocampal-neocortical communication. Although experimental evidence supports the role of sharp-wave ripples in transferring hippocampal information to the neocortex, the exact cortical destinations and the physiological mechanisms of such transfer are not known. We used a conducting polymer-based conformable microelectrode array (NeuroGrid) to record local field potentials and neural spiking across the dorsal cortical surface of the rat brain, combined with silicon probe recordings in the hippocampus, to identify candidate physiological patterns. Parietal, midline, and prefrontal, but not primary cortical areas, displayed localized ripple (100 to 150 hertz) oscillations during sleep, concurrent with hippocampal ripples. Coupling between hippocampal and neocortical ripples was strengthened during sleep following learning. These findings suggest that ripple-ripple coupling supports hippocampal-association cortical transfer of memory traces.
Source: Science
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: HIPPOCAMPAL INTERNEURONAL NETWORK, Towards a Complete Description of the Circuitry Underlying Memory replay., Modular High-Density Optoelectrodes for Local Circuit Analysis, NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surface, Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory Replay, G649618751, Brain rhythms-assisted memory enhancement
OpenAlex ID: W2765562806