Work

Outside‐In Systems Pharmacology Combines Innovative Computational Methods With High‐Throughput Whole Vertebrate Studies

Year: 2018

Type: article

Abstract: To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside-in model development, a model identification technique to understand and predict the dynamics of a system without requiring prior biological and/or pharmacological knowledge. The advanced data required could be obtained by whole vertebrate, high-throughput, low-resource dose-exposure-effect experimentation with the zebrafish larva. Combinations of these innovative techniques could improve early drug discovery.

Source: CPT Pharmacometrics & Systems Pharmacology

DOI: 10.1002/psp4.12297

Authors: Pascal Schulthess, Rob C. van Wijk, Elke H. J. Krekels, James W. T. Yates, Herman P. Spaink, Piet H. van der Graaf

Institutions: Leiden University, AstraZeneca (United Kingdom)

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,140