Work

Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation

Year: 2018

Type: article

Abstract: Key Points Shear-induced, Gα13-mediated integrin outside-in signaling facilitates platelet PS exposure, MV release, and coagulation. An inhibitor of outside-in signaling inhibits not only occlusive platelet thrombus formation but also intravascular coagulation in vivo.

Source: Blood

DOI: 10.1182/blood-2017-05-785253

Authors: Aiming Pang, Yujie Cui, Yunfeng Chen, Ni Cheng, M. Keegan Delaney, Minyi Gu, Aleksandra Stojanovic-Terpo, Cheng Zhu, Xiaoping Du

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, University of Illinois Chicago, Institute of Hematology & Blood Diseases Hospital, Tianjin Medical University, Georgia Institute of Technology

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, University of Illinois at Urbana-Champaign, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: G1973800855, G2131744332, G2367451870, G595708635, G6837735701, G7087393447, G7090553423, G7535686976, KINETIC PROPERTIES OF SELECTINS

OpenAlex ID: W2805499461

FWCI: 5.927

Cites: 53

Cited by: 86

Related to: 10