Work

Inflammatory responses after intracerebral hemorrhage: From cellular function to therapeutic targets

Year: 2018

Type: article

Abstract: Inflammatory responses occur rapidly after intracerebral hemorrhage and participate in both short-term toxicity and long-term recovery. Microglia/macrophages react to hemorrhagic injury and exhibit dynamic phenotypes and phagocytic capability. Astrocytes secrete cytokines, chemokines, and gliotransmitters that can regulate neuroinflammation. In addition, infiltrating neutrophils and T-lymphocytes modulate immunoreactions, which further cross-talk with microglia/macrophages. Thus, the search for effective immunotherapy to target specific cell type-mediated inflammation might represent a new direction for intracerebral hemorrhage treatment, separate from traditional anti-inflammatory drug discovery.

Source: Journal of Cerebral Blood Flow & Metabolism

DOI: 10.1177/0271678x18805675

Authors: Xi Lan, Xiaoning Han, Xi Liu, Jian Wang

Institutions: Johns Hopkins University, Johns Hopkins Medicine, First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Intracerebral and Subarachnoid Hemorrhage Research

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institute of Neurological Disorders and Stroke, National Center for Complementary and Integrative Health