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BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

Year: 2018

Type: article

Abstract: (Cell Reports 24, 3513–3527.e1–e7; September 25, 2018) Due to an error in the production process, Table 1 contained two errors. In the second row of the table, Brca1+/+ was incorrectly labeled as Brca1ΔC/ΔC, and Brca1+/ΔC was incorrectly labeled as Brca1+/+. These errors have been corrected, and the revised version of Table 1 now appears with the paper online. The production team apologizes for this error. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor ResistanceNacson et al.Cell ReportsSeptember 25, 2018In BriefUsing a Brca1ΔC mouse model and a panel of BRCA1 mutant cancer cell lines, Nacson et al. show that 53BP1 loss of function induced homologous recombination and PARP inhibitor resistance is suboptimal in the absence of hypomorphic BRCA1 proteins that retain the coiled-coil domain and ability to interact with PALB2. Full-Text PDF Open Access

Source: Cell Reports

DOI: 10.1016/j.celrep.2018.10.009