Work

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Year: 2019

Type: article

Abstract: Afferents modulate newborn neurons What is the role of adult neurogenesis in learning, memory, and mood? Luna et al. found that adult-born neurons either inhibited or excited the dentate gyrus, depending on whether synaptic inputs originated from the lateral or the medial entorhinal cortex (see the Perspective by Llorens-Martín). These opposing mechanisms were driven by extrasynaptic transmission from adult-born neurons directly onto mature granule cells via metabotropic glutamate receptors or N -methyl- D -aspartate receptors, respectively. The balance between these mechanisms could explain the differences in dentate gyrus activity during two versions of an active place-avoidance task. The action of adult-born neurons thus depended entirely on the demands of the environment, which can be defined by the activity of cortical and subcortical regions sending inputs to the dentate gyrus. Science , this issue p. 578 ; see also p. 530

Source: Science

DOI: 10.1126/science.aat8789

Authors: Victor M. Luna, Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, Rebecca Ravenelle, Jessica C. Jimenez, Alessia Mastrodonato, Christine A. Denny, Andre A. Fenton, Helen E. Scharfman, Rene Hen

Institutions: Research Foundation For Mental Hygiene, New York State Psychiatric Institute, Columbia University, The Graduate Center, CUNY, City University of New York, Hunter College, NYU Langone Health, New York University, State University of New York, SUNY Downstate Health Sciences University

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, New York Stem Cell Foundation, Hope for Depression Research Foundation, National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities

Awards: Basic and Translational Research Center for Reducing Health Disparities, G1655618803, Cellular Mechanisms of Antidepressant Action, Adult hippocampal neuroplasticity and depression, G248017920, Diverse Roles of Adult Dentate Gyrus Neurogenesis, Identifying cellular and molecular substrates of treatment-resistant depression., The Impact of Increasing Neurogenesis on Cognitive Deficits Related to Aging, Optogenetic dissection of hippocampal circuitry underlying Alzheimers disease, Hippocampal neurogenesis, pattern separation & age-related cognitive impairments., G7022634188, IDENTIFYING CELLULAR AND MOLECULAR SUBSTRATES OF TREATMENT-RESISTANT DEPRESSION., G8437437002, 2-photon microscope for in vivo functional imaging of neuronal circuits, Circuits underlying overgeneralization

OpenAlex ID: W2943879438

FWCI: 8.909

Cites: 40

Cited by: 180

Related to: 10