Long-duration hippocampal sharp wave ripples improve memory
Year: 2019
Type: article
Abstract: Hippocampal sharp wave ripples (SPW-Rs) have been hypothesized as a mechanism for memory consolidation and action planning. The duration of ripples shows a skewed distribution with a minority of long-duration events. We discovered that long-duration ripples are increased in situations demanding memory in rats. Prolongation of spontaneously occurring ripples by optogenetic stimulation, but not randomly induced ripples, increased memory during maze learning. The neuronal content of randomly induced ripples was similar to short-duration spontaneous ripples and contained little spatial information. The spike content of the optogenetically prolonged ripples was biased by the ongoing, naturally initiated neuronal sequences. Prolonged ripples recruited new neurons that represented either arm of the maze. Long-duration hippocampal SPW-Rs replaying large parts of planned routes are critical for memory.
Source: Science
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: NeuroNex Technology Hub: Multimodal Integrated Neural Technologies (MINT) - Connecting Physiology to Functional Mapping, Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory Replay, Brain rhythms-assisted memory enhancement, G6769717331, Hippocampo-cortical circuit mechanisms of neuronal sequences during learning, Deducing the origin and effect of extracellular electric fields in hippocampus, Hippocampal-subcortical interactions underlying social memory, Neural dynamics underlying brain state-dependent memory functions
OpenAlex ID: W2949722813