Work

Expeditious Synthesis of Isoquinolones and Isocoumarins with a Vinyl Borane as an Acetylene Equivalent

Year: 2016

Type: article

Abstract: An innovative and simple expeditious synthesis of 3,4‐unsubstituted isoquinolones and isocoumarins starting from a safe and easy‐to‐handle two‐carbon acetylene equivalent was developed. The synthetic potential of this new method was further demonstrated in the facile total synthesis of two naturally occurring alkaloids, corydaldine and doryanine.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201600575

Authors: Momar Toure, Saul Jaime‐Figueroa, George M. Burslem, Craig M. Crews

Institution: Yale University

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Leukemia and Lymphoma Society, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: A MULTIPRONGED, PROTEIN DEGRADATION-BASED APPROACH TO INHIBIT HIV TRANSMISSION, Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities