Work

Gastrointestinal Polyposis in Pediatric Patients

Year: 2019

Type: review

Abstract: Gastrointestinal polyps are mucosal overgrowths that, if unchecked, can undergo malignant transformation. Although relatively uncommon in the pediatric age group, they can be the harbingers of multiorgan cancer risk and require close management and follow-up. Additionally, as many polyposis syndromes are inherited, appropriate genetic testing and management of relatives is vital for the health of the entire family. In this review, we discuss both common and uncommon childhood gastrointestinal polyposis syndromes in terms of clinical presentation, management, and surveillance. We also detail any additional malignancy risk and surveillance required in the pediatric age group (<21 years old). Through this review, we provide a framework for gastroenterologists to manage the multifaceted nature of pediatric polyposis syndromes.

Source: Journal of Pediatric Gastroenterology and Nutrition

DOI: 10.1097/mpg.0000000000002421

Authors: Suzanne P. MacFarland, Kristin Zelley, Bryson W. Katona, Benjamin J. Wilkins, Garrett M. Brodeur, Petar Mamula

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development