Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides
Year: 2019
Type: review
Abstract: Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues. Studies have explored interventions using collagen-targeting tissue engineered techniques, using collagen hybridizing or collagen binding peptides, to target or treat dysregulated or injured collagen in developmental defects, injuries, and diseases. Researchers have used collagen-targeting peptides to deliver growth factors, drugs, and genetic materials, to develop bioactive surfaces, and to detect the distribution and status of collagen. All of these approaches have been used for various regenerative medicine applications, including neovascularization, wound healing, and tissue regeneration. In this review, we describe in depth the collagen-targeting approaches for regenerative therapeutics and compare the benefits of using the different molecules for various present and future applications.
DOI: 10.3390/ijms20174072
Authors: Leora Goldbloom-Helzner, Dake Hao, Aijun Wang
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,824
Funders: March of Dimes Foundation, Shriners Hospitals for Children, National Institutes of Health, University of California, Davis, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, University of California Davis School of Medicine
Awards: G1066339543, G1272335794, G1636620865, G203354908, G2307300562, G2548680409, G2659888700, G2711536303, G2826625206, G3408698656, G3608626411, G3694532710, G3847428086, Guinea pigs as a model of in utero stem cell therapy for spina bifida, G420600422, Fetal Tissue Engineering to Treat Spina Bifida Before Birth, G4266307509, G477963360, G4996605879, G547291771, G5852404115, G7158873286, G7329987156, G7782619123, G813156335, UC BRAID Center for Accelerated Innovation, UC Davis Clinical and Translational Science Center
OpenAlex ID: W2969875971