A Topological Loss Function for Deep-Learning Based Image Segmentation Using Persistent Homology
Year: 2020
Type: article
Abstract: We introduce a method for training neural networks to perform image or volume segmentation in which prior knowledge about the topology of the segmented object can be explicitly provided and then incorporated into the training process. By using the differentiable properties of persistent homology, a concept used in topological data analysis, we can specify the desired topology of segmented objects in terms of their Betti numbers and then drive the proposed segmentations to contain the specified topological features. Importantly this process does not require any ground-truth labels, just prior knowledge of the topology of the structure being segmented. We demonstrate our approach in four experiments: one on MNIST image denoising and digit recognition, one on left ventricular myocardium segmentation from magnetic resonance imaging data from the UK Biobank, one on the ACDC public challenge dataset and one on placenta segmentation from 3-D ultrasound. We find that embedding explicit prior knowledge in neural network segmentation tasks is most beneficial when the segmentation task is especially challenging and that it can be used in either a semi-supervised or post-processing context to extract a useful training gradient from images without pixelwise labels.
Institutions: King's College London, Istanbul Technical University
Language: English
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,045
Funders: Nvidia, Wellcome Trust, National Institute for Health and Care Research, King's College London, Medical Research Council, Engineering and Physical Sciences Research Council, Menzies Centre for Australian Studies, King's College London, University of London, Guy's and St Thomas' NHS Foundation Trust, Centre For Medical Engineering, King’s College London
Awards: G1211483440, G1247657515, King's College London Medical Engineering Centre of Research Excellence, G1435826916, G152311697, G1814604835, G1961329086, A computer-guided imaging system for prenatal screening and comprehensive diagnosis of fetal abnormalities., G2417159676, SmartHeart: Next-generation cardiovascular healthcare via integrated image acquisition, reconstruction, analysis and learning, Patient-specific care at the cutting-edge of paediatric cardiology practice: a 3D window on anatomy at the intersection of medical imaging, computer science and 3D printing, G3842836504, EPSRC-NIHR HTC Partnership Award 'Plus': Medical Image Analysis Network (MedIAN), G5296857752, G5847502682, G5850737185, King's College London Medical Engineering Centre of Research Excellence, G6333133484, G7082644654, G751609732, G81539058, G8303168876, G8775246936, G938335843, G961285871
OpenAlex ID: W2978005227
