Work

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis

Year: 2019

Type: article

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2019.115125

Authors: Weiguo Xiang, Aamod Dekhne, Arpit Doshi, Carrie O'Connor, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee

Institutions: Duquesne University, Wayne State University, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Duquesne University, National Institutes of Health, National Cancer Institute

Awards: Purine Synthesis Inhibitors with Selective Folate Receptor Tumor Transport, G507535757, G7013115585, G7187270203, G7293752056, G861968229, G9000197037, G9000230479, G9000324509, Training Program in the Biology of Cancer

OpenAlex ID: W2980871024

FWCI: 0.143

Cites: 50

Cited by: 2

Related to: 10