Year: 2019
Type: review
Abstract: Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress which interconnects with other processes such as amyloid-β deposition, tau hyperphosphorylation, and tangle formation. This review discusses current thoughts on molecular mechanisms that may relate oxidative stress to Alzheimer's disease and identifies genetic factors observed from in vitro, in vivo, and clinical studies that may be associated with Alzheimer's disease-related oxidative stress.
Source: Journal of Alzheimer s Disease
DOI: 10.3233/jad-190863
Authors: Federica Cioffi, Rayan Hassan Ibrahim Adam, Kerensa Broersen
Institution: University of Twente
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Funder: ZonMw
Award: G2224223232
OpenAlex ID: W2984421981