Prepregnancy obesity is associated with cognitive outcomes in boys in a low-income, multiethnic birth cohort
Year: 2019
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Maternal obesity and high gestational weight gain (GWG) disproportionally affect low-income populations and may be associated with child neurodevelopment in a sex-specific manner. We examined sex-specific associations between prepregnancy BMI, GWG, and child neurodevelopment at age 7. METHODS: Data are from a prospective low-income cohort of African American and Dominican women (n = 368; 44.8% male offspring) enrolled during the second half of pregnancy from 1998 to 2006. Neurodevelopment was measured using the Wechsler Intelligence Scale for Children (WISC-IV) at approximately child age 7. Linear regression estimated associations between prepregnancy BMI, GWG, and child outcomes, adjusting for race/ethnicity, marital status, gestational age at delivery, maternal education, maternal IQ and child age. RESULTS: Overweight affected 23.9% of mothers and obesity affected 22.6%. At age 7, full-scale IQ was higher among girls (99.7 ± 11.6) compared to boys (96.9 ± 13.3). Among boys, but not girls, prepregnancy overweight and obesity were associated with lower full-scale IQ scores [overweight β: - 7.1, 95% CI: (- 12.1, - 2.0); obesity β: - 5.7, 95% CI: (- 10.7, - 0.7)]. GWG was not associated with full-scale IQ in either sex. CONCLUSIONS: Prepregnancy overweight and obesity were associated with lower IQ among boys, but not girls, at 7 years. These findings are important considering overweight and obesity prevalence and the long-term implications of early cognitive development.
Source: BMC Pediatrics
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,290
Funders: U.S. Environmental Protection Agency, New York Community Trust, Thrasher Research Fund, Educational Foundation of America, Blanchette Hooker Rockefeller Fund, John and Wendy Neu Foundation, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular health, G1809521395, G3081240819, Pregnancy weight trajectories and offspring adiposity, G3170494751, G3478281036, G4108274008, The Columbia Center for Children's Environmental Health, G4524159699, Pregnancy weight trajectories and offspring adiposity, G592978787, G5985371418, G6454822134, G654971837, G687837420, G7606320433, G765640669, G8040230839, GENERAL CLINICAL RESEARCH CENTER, Population Research Center, New York Regional Center for Diabetes Translation Research, Center for Environmental Health in Northern Manhattan
OpenAlex ID: W2996092218