Year: 2020
Type: article
Abstract: Sepsis is a systemic inflammatory response to infection and a leading cause of death. Mucosal-associated invariant T (MAIT) cells are innate-like T cells enriched in mucosal tissues that recognize bacterial ligands. We investigated MAIT cells during clinical and experimental sepsis, and their contribution to host responses. In experimental sepsis, MAIT-deficient mice had significantly increased mortality and bacterial load, and reduced tissue-specific cytokine responses. MAIT cells of WT mice expressed lower levels of IFN-γ and IL-17a during sepsis compared to sham surgery, changes not seen in non-MAIT T cells. MAIT cells of patients at sepsis presentation were significantly reduced in frequency compared to healthy donors, and were more activated, with decreased IFN-γ production, compared to both healthy donors and paired 90-day samples. Our data suggest that MAIT cells are highly activated and become dysfunctional during clinical sepsis, and contribute to tissue-specific cytokine responses that are protective against mortality during experimental sepsis.
Source: eLife
DOI: 10.7554/elife.55615
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: U.S. Department of Veterans Affairs, University of Utah, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
Awards: G1774981225, Platelet Immune Responses in Aging and Influenza, Interferon-Induced Transmembrane Protein 3 (IFITM3) Regulates Thrombosis During Inflammation in Aging, G4814311130, Novel Platelet Functions in Sepsis and Venous Thromboembolism, Utah Center for Clinical and Translational Science, G6146018673, NRSA Training Core, G749063782, G7517808149, Impact of Flagellin Variants and Receptors on the Progression and Outcome of Sepsis, Mucosal associated invariant T (MAIT) cells in Vibrio cholerae infection and vaccination, The Regulation of Inflammatory Gene Responses in Aging, Training Program in Genomic Medicine, G999781830
OpenAlex ID: W3103699740