Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier
Year: 2020
Type: article
Abstract: ) exhibit increased retinal vascular leakage and enhanced endothelial transcytosis. Wnt signaling directly controls the transcription of an endothelium-specific transcytosis inhibitor, major facilitator superfamily domain-containing protein 2a (MFSD2A), in a β-catenin-dependent manner. MFSD2A overexpression reverses Wnt deficiency-induced transcytosis in endothelial cells and in retinas. Moreover, Wnt signaling mediates MFSD2A-dependent vascular endothelium transcytosis through a caveolin-1 (CAV-1)-positive caveolae pathway. In addition, levels of omega-3 fatty acids are also decreased in Wnt signaling-deficient retinas, reflecting the basic function of MFSD2A as a lipid transporter. Our findings uncovered the Wnt/β-catenin/MFSD2A/CAV-1 axis as a key pathway governing endothelium transcytosis and inner BRB integrity.
Source: Science Advances
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,500
Awards: Wnt Signaling and Vertebrate embryogenesis, The Mechanism of Immune-Vascular Crosstalk in Retinopathy, Photoreceptor Determination of Retinal Blood Vessel Growth in Retinopathy, Boston Intellectual and Developmental Disabilities Research Center, Wnt signaling-mediated control of blood-retinal barrier, Intellectual and Developmental Disablities Research Center, RORalpha mediates chronic subretinal inflammation associated with AMD
OpenAlex ID: W3081763731