Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis
Year: 2021
Type: article
Study design: Observational Study
Abstract: Evidence on the long-term risk of HIV infection in individuals taking HIV post-exposure prophylaxis remains limited. In this retrospective data linkage study, we evaluate the occurrence of HIV infection in 975 individuals who sought post-exposure prophylaxis in a tertiary hospital between 2007 and 2013. Using privacy preserving probabilistic linkage, we link these 975 records with two observational databases providing data on HIV events (Zurich Primary HIV Infection study and the Swiss HIV Cohort Study). This enables us to identify 22 HIV infections and to obtain long-term follow-up data, which reveal a median of 4.1 years between consultation for post-exposure prophylaxis and HIV diagnosis. Even though men who have sex with men constitute only 35.8% of those seeking post-exposure prophylaxis, all 22 events occur in this subgroup. These findings should strongly encourage early consideration of pre-exposure prophylaxis in men who have sex with men after a first episode of post-exposure prophylaxis.
Source: Nature Communications
Authors: Frédérique Hovaguimian, Huldrych F. Günthard, Christoph Hauser, Anna Conen, Enos Bernasconi, Alexandra Calmy, Matthias Cavassini, Marco Seneghini, Alex Marzel, Henriette Heinrich, Alexandra Scherrer, Julien Riou, Adrian Spoerri, Kurt Schmidlin, Suraj Balakrishna, Dominique L. Braun, Silvana K. Rampini, Jan S. Fehr, Roger D. Kouyos, the Swiss HIV Cohort Study, K. Aebi-Popp, A. Anagnostopoulos, M. Battegay, E. Bernasconi, J. Böni, D. L. Braun, H. C. Bucher, A. Calmy, M. Cavassini, A. Ciuffi, G. Dollenmaier, M. Egger, L. Elzi, J. Fehr, J. Fellay, H. Furrer, C. A. Fux, H. F. Günthard, D. Haerry, B. Hasse, H. H. Hirsch, M. Hoffmann, I. Hösli, M. Huber, C. R. Kahlert, L. Kaiser, O. Keiser, T. Klimkait, R. D. Kouyos, H. Kovari, B. Ledergerber, G. Martinetti, B. Martinez de Tejada, C. Marzolini, K. J. Metzner, N. Müller, D. Nicca, P. Paioni, G. Pantaleo, M. Perreau, A. Rauch, C. Rudin, A. U. Scherrer, P. Schmid, R. Speck, M. Stöckle, P. Tarr, A. Trkola, P. Vernazza, G. Wandeler, R. Weber, S. Yerly
Institutions: University of Zurich, University Hospital Zurich, University of Bern, University Hospital of Bern, Kantonsspital Aarau, Ospedale regionale di Lugano, University Hospital of Geneva, Centre Hospitalier Universitaire Vaudois, Kantonsspital St. Gallen, Schulthess-Klinik, Triemli Hospital, University of Basel, University Hospital of Basel, University of Lausanne, École Polytechnique Fédérale de Lausanne, Ostschweizer Kinderspital, University of Geneva, University Children's Hospital Zurich, University Children’s Hospital Basel, Kantonsspital Baselland
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,560
OpenAlex ID: W3130634196