Work

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Year: 2021

Type: article

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2021.116093

Authors: Adrianne Wallace-Povirk, Nian Tong, Jennifer Wong-Roushar, Carrie O'Connor, Xilin Zhou, Zhanjun Hou, Xun Bao, Gloria E. Garcia, Jing Li, Seongho Kim, Charles E. Dann, Larry H. Matherly, Aleem Gangjee

Institutions: Wayne State University, Duquesne University, Indiana University Bloomington, Indiana University, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Biochemical and Molecular Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Energy, Wayne State University, Duquesne University, Barbara Ann Karmanos Cancer Institute, National Institutes of Health, Office of Science, National Cancer Institute, National Institute of General Medical Sciences, Argonne National Laboratory

Awards: G107546177, G1446778969, G2421253178, Purine Synthesis Inhibitors with Selective Folate Receptor Tumor Transport, G507535757, Targeting Mitochondrial One-Carbon Metabolism in Epithelial Ovarian Cancer, G7013115585, G7191493237, G7293752056, G861968229, G9000009483, G9000197037, G9000230479, G9000324509, CANCER CENTER SUPPORT GRANT

OpenAlex ID: W3131181900

FWCI: 0.738

Cites: 72

Cited by: 12

Related to: 10