Work

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

Year: 2022

Type: article

Source: Nature Genetics

DOI: 10.1038/s41588-022-01087-y

Authors: Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, Kushal K. Dey, Joseph Nasser, Karthik A. Jagadeesh, Daniel J. Weiner, Huwenbo Shi, Charles P. Fulco, Luke J. O’Connor, Bogdan Pasaniuc, Jesse M. Engreitz, Alkes L. Price

Institutions: Broad Institute, University of Southern California, Harvard University, Bristol-Myers Squibb (United States), University of California, Los Angeles, Lucile Packard Children's Hospital, Stanford Medicine, Stanford University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, Medical Research Council, National Institute of Mental Health, National Human Genome Research Institute

Awards: G1021745955, From common to rare variant functional architectures of human diseases, G223491490, G3177290858, Leveraging functional data to predict disease risk in multi-ethnic populations, Network-based prediction and validation of causal schizophrenia genes and variants, G5850737185, G6254203004, New approaches for leveraging single-cell data to identify disease-critical genes and gene sets, Functionally specialized components of disease heritability in ENCODE data, G7523544532, G8088770145, G9000286330, Statistical methods to localize disease heritability and identify biological mechanisms, Training in Bioinformatics and Integrative Genomics, Functional and population genetic architectures of complex disease, Integrating case-control transcriptomic and genetic data in admixed individuals to identify disease genes for schizophrenia and bipolar disorder, Predicting the impact of genetic variants, genes and pathways on human Disease

OpenAlex ID: W4282915079

FWCI: 22.61

Cites: 103

Cited by: 181

Related to: 10