Work

Photochemical synthesis of an epigenetic focused tetrahydroquinoline library

Year: 2021

Type: article

Abstract: , kinases) resulting in low hit rates for epigenetic targets. Here we describe the design and synthesis of a compound collection that augments current screening collections by the inclusion of privileged isosteres for epigenetic targets.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d1md00193k

Authors: Adam I. Green, George M. Burslem

Institution: University of Pennsylvania

Language: English

Topic: Isoquinoline Alkaloid Synthesis

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, Vagelos Institute for Energy Science and Technology, University of Pennsylvania, National Institute of General Medical Sciences

Awards: Computational Methods for Selective Catalysis, MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for Chemistry and Energy Research and Education at the University of Pennsylvania, Targeting Nucleic Acid Junctions with Small Molecules

OpenAlex ID: W3194086901

FWCI: 0.395

Cites: 36

Cited by: 7

Related to: 10