Work

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA

Year: 2021

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.1c01250

Authors: Yanran Lu, Sandip Vibhute, Linsen Li, Antony Okumu, Steven C. Ratigan, Sheri Nolan, Jonathan L. Papa, Chelsea A. Mann, Anthony English, Anna Chen, Justin T. Seffernick, Bryan Koci, Leonard R. Duncan, Brieanna Roth, Jason E. Cummings, Richard A. Slayden, Steffen Lindert, Craig A. McElroy, Daniel J. Wozniak, Jack Yalowich, Mark J. Mitton-Fry

Institutions: The Ohio State University, Eurofins (United States), JMI Laboratories, Colorado State University

Language: English

Topic: Cancer therapeutics and mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Cystic Fibrosis Foundation, Ohio State University, Dr. Ralph and Marian Falk Medical Research Trust

Award: G8345523870

OpenAlex ID: W3201738083

FWCI: 2.04

Cites: 68

Cited by: 40

Related to: 10