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A large fraction of trisomy 12, 17p − , and 11q − CLL cases carry unidentified microdeletions of miR-15a/16-1

Year: 2022

Type: article

Abstract: Significance 13q14.3 deletion is the most common genetic lesion identified in CLLs. This study shows that microdeletions affecting the miR-15a/16-1 cluster are more frequent than expected in all CLL cohorts and are prevalent in patients carrying a trisomy 12. Copy-number variation analysis and an experimental FISH analysis revealed that ∼34% of samples carry previously unidentified microdeletions of miR-15a/16-1 . These data may have clinical relevance for the successful stratification of patients for treatment.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.2118752119