Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The relation between blood pressure and kidney cancer risk is well established but complex and different study designs have reported discrepant findings on the relative importance of diastolic blood pressure (DBP) and systolic blood pressure (SBP). In this study, we sought to describe the temporal relation between diastolic and SBP with renal cell carcinoma (RCC) risk in detail. METHODS: Our study involved two prospective cohorts: the European Prospective Investigation into Cancer and Nutrition study and UK Biobank, including >700 000 participants and 1692 incident RCC cases. Risk analyses were conducted using flexible parametric survival models for DBP and SBP both separately as well as with mutuality adjustment and then adjustment for extended risk factors. We also carried out univariable and multivariable Mendelian randomization (MR) analyses (DBP: ninstruments = 251, SBP: ninstruments = 213) to complement the analyses of measured DBP and SBP. RESULTS: In the univariable analysis, we observed clear positive associations with RCC risk for both diastolic and SBP when measured ≥5 years before diagnosis and suggestive evidence for a stronger risk association in the year leading up to diagnosis. In mutually adjusted analysis, the long-term risk association of DBP remained, with a hazard ratio (HR) per standard deviation increment 10 years before diagnosis (HR10y) of 1.20 (95% CI: 1.10-1.30), whereas the association of SBP was attenuated (HR10y: 1.00, 95% CI: 0.91-1.10). In the complementary multivariable MR analysis, we observed an odds ratio for a 1-SD increment (ORsd) of 1.34 (95% CI: 1.08-1.67) for genetically predicted DBP and 0.70 (95% CI: 0.56-0.88) for genetically predicted SBP. CONCLUSION: The results of this observational and MR study are consistent with an important role of DBP in RCC aetiology. The relation between SBP and RCC risk was less clear but does not appear to be independent of DBP.
DOI: 10.1093/ije/dyac042
Authors: Karine Alcala, Daniela Mariosa, Karl Smith-Byrne, Dariush Nasrollahzadeh Nesheli, Robert Carreras-Torres, Eva Ardanaz Aicua, Nicola P Bondonno, Catalina Bonet, Mattias Brunström, Bas Bueno-de-Mesquita, María-Dolores Chirlaque, Sofia Christakoudi, Alicia K Heath, Rudolf Kaaks, Verena Katzke, Vittorio Krogh, Börje Ljungberg, Richard M Martin, Anne May, Olle Melander, Domenico Palli, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Tanja Stocks, Anne Tjønneland, Ruth C Travis, Roel Vermeulen, Stephen Chanock, Mark Purdue, Elisabete Weiderpass, David Muller, Paul Brennan, Mattias Johansson
Institutions: Centre international de recherche sur le cancer, University of Oxford, Institut d'Investigació Biomèdica de Girona, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Edith Cowan University, The University of Western Australia, Royal Perth Hospital, Danish Cancer Society, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Umeå University, National Institute for Public Health and the Environment, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, King's College London, Imperial College London, German Cancer Research Center, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Bristol, Utrecht University, University Medical Center Utrecht, Lund University, Skåne University Hospital, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Copenhagen, National Institutes of Health, Division of Cancer Epidemiology and Genetics
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Cancer Research UK, National Institute for Health and Care Research, Imperial College London, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, NIHR Imperial Biomedical Research Centre, School of Public Health, Imperial College London
Awards: G1055973116, G1131969086, G1192877484, G1478484880, G1767199718, G1993546569, G2027148636, G2131326840, G2235605558, G2409987178, G2539064604, G2572521044, G2742323354, G2803518814, G2809956348, G29072894, G2933204024, G3077395769, G3189789075, G3216658785, G323433674, G324601231, G3328679326, G3544161537, G3747421453, G375319704, G382879149, G4089957676, G4187108342, G4213141252, G4303038735, Health of vegetarians, G459595259, G4844208673, G4879533352, G5004963360, G5271742736, G5288121262, G558017500, G5850737185, G5897142711, G5990830295, G6085534252, G6442500046, NIHR Senior Investigator Award, G6766485657, G6923329853, G7426181285, G7447125227, G7597388277, G7646326732, G7677770324, G7908684568, G8050896463, G8279237360, G8846336397, G8959392569, G8978728421, G9000040826, G9000332718
OpenAlex ID: W4220909471