Work

Exosome-Mediated Angiogenesis Underlies LVAD-Induced Bleeding in Patients With End-Stage Heart Failure

Year: 2022

Type: article

Abstract: T he von Willebrand factor (VWF), named after the Finnish physician who first described the hereditary disorder caused by its deficiency, is a large glycoprotein, synthesized in megakaryocytes and endothelial cells, that undergoes extensive post-translational processing. 1 The basic VWF monomer contains 2,050 amino acids; the multimeric structure of VWF, which can be exceptionally large (>20,000 kDa), makes the protein sensitive to changes in fluid flow and shear stress.Multimers of VWF are stored within the Weibel-Palade bodies in endothelial cells and a granules in megakaryocytes and platelets.High molecular weight VWF multimers

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2022.01.011

Authors: Pasquale Mone, Antonella Pansini, Fahimeh Varzideh, Antonio de Donato, Stanislovas S. Jankauskas, Gaetano Santulli

Institutions: Albert Einstein College of Medicine, University of Campania "Luigi Vanvitelli", University of Naples Federico II

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,400