Work

AIP1: a new player in TNF signaling

Year: 2003

Type: article

Abstract: Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting protein, AIP1, plays an important role in TNF-alpha-induced ASK1 activation by facilitating dissociation from its inhibitor.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci18911

Authors: M. Eugenia Guicciardi, Gregory J. Gores

Institutions: Mayo Clinic, University of Arizona

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Mayo Foundation for Medical Education and Research, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1214035053, G2030504644, G9000043987