Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis
Year: 2022
Type: preprint
Study design: Observational Study
Abstract: Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We conducted genome-wide association studies of short (≤5 hours) and long (≥10 hours) sleep duration in adults of European, African, East Asian, and admixed-American ancestry from UK Biobank and the Million Veteran Program. In a cross-population meta-analysis we identified 84 independent loci for short sleep and 1 for long sleep. We estimated SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identified positive genetic correlation between short and long sleep traits (r g = 0.16±0.04; P=0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation revealed a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.
Source: medRxiv
Authors: Isabelle Austin-Zimmerman, Daniel F. Levey, Olga Giannakopoulou, Joseph D. Deak, Marco Galimberti, Hang Zhou, Spiros Denaxas, Haritz Irizar, Karoline Kuchenbaecker, Andrew McQuillin, the Million Veteran Program, John Concato, Daniel J. Buysse, J. Michael Gaziano, Daniel J. Gottlieb, Renato Polimanti, Murray B. Stein, Elvira Bramon, Joel Gelernter
Institutions: King's College London, University College London, Yale University, VA Connecticut Healthcare System, Health Data Research UK, Icahn School of Medicine at Mount Sinai, United States Food and Drug Administration, Center for Drug Evaluation and Research, University of Pittsburgh, Brigham and Women's Hospital, Harvard University, VA Boston Healthcare System, University of California San Diego, VA San Diego Healthcare System
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Yale University, Office of Research and Development, National Alliance for Research on Schizophrenia and Depression, Wellcome Trust, European Commission, National Institutes of Health, Medical Research Council, National Institute on Alcohol Abuse and Alcoholism, National Institute of Allergy and Infectious Diseases
OpenAlex ID: W4295031250