Work

miR-4432 Targets FGFBP1 in Human Endothelial Cells

Year: 2023

Type: article

Abstract: MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of several target genes. Fibroblast growth factor binding protein 1 (FGFBP1) has been associated with endothelial dysfunction at the level of the blood-brain barrier (BBB). However, the underlying mechanisms are mostly unknown and there are no studies investigating the relationship between miRs and FGFBP1. Thus, the overarching aim of the present study was to identify and validate which miR can specifically target FGFBP1 in human brain microvascular endothelial cells, which represent the best in vitro model of the BBB. We were able to identify and validate miR-4432 as a fundamental modulator of FGFBP1 and we demonstrated that miR-4432 significantly reduces mitochondrial oxidative stress, a well-established pathophysiological hallmark of hypertension.

Source: Biology

DOI: 10.3390/biology12030459

Authors: Roberta Avvisato, Pasquale Mone, Stanislovas S. Jankauskas, Fahimeh Varzideh, Urna Kansakar, Jessica Gambardella, Antonio De Luca, Alessandro Matarese, Gaetano Santulli

Institutions: Albert Einstein College of Medicine, University of Naples Federico II, University of Campania "Luigi Vanvitelli", Ospedale Antonio Cardarelli

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,447

Funders: American Heart Association, Diabetes Action Research and Education Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences

Awards: G1000608447, G1182331892, G1196682224, G1218068299, Molecular regulation of skeletal muscle thermogenesis, G1512127578, G180476886, Beta Cell Intracellular Calcium and Diabetes, Functional role of IP3 receptors in the regulation of cardiac myofibroblasts, G3069166775, G6613182410, G7698634250, G790170206, G802470759

OpenAlex ID: W4327729663

FWCI: 0.776

Cites: 51

Cited by: 8

Related to: 10