Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study
Year: 2023
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Bone mineral density (BMD) loss may be accelerated in people with HIV (PLWH). It is unknown whether a polygenic risk score (PRS) is associated with low BMD in PLWH. METHODS: Swiss HIV Cohort Study participants of self-reported European descent underwent ≥2 per-protocol dual x-ray absorptiometry (DXA) measurements ≥2 years apart (2011-2020). Univariable and multivariable odds ratios (ORs) for DXA-defined osteoporosis were based on traditional and HIV-related risk factors and a genome-wide PRS built from 9413 single-nucleotide polymorphisms associated with low BMD in the general population. Controls were free from osteoporosis/osteopenia on all DXA measurements. RESULTS: We included 438 participants: 149 with osteoporosis and 289 controls (median age, 53 years; 82% male, 95% with suppressed HIV RNA). Participants with unfavorable osteoporosis PRS (top vs bottom quintile) had univariable and multivariable-adjusted osteoporosis ORs of 4.76 (95% CI, 2.34-9.67) and 4.13 (1.86-9.18), respectively. For comparison, hepatitis C seropositivity, 5-year tenofovir disoproxil fumarate exposure, and parent history of hip fracture yielded univariable osteoporosis ORs of 2.26 (1.37-3.74), 1.84 (1.40-2.43), and 1.54 (0.82-2.9). CONCLUSIONS: In PLWH in Switzerland, osteoporosis was independently associated with a BMD-associated PRS after adjustment for established risk factors, including exposure to tenofovir disoproxil fumarate.
Authors: Johannes M Schwenke, Christian W Thorball, Isabella C Schoepf, Lene Ryom, Barbara Hasse, Olivier Lamy, Alexandra Calmy, Gilles Wandeler, Catia Marzolini, Christian R Kahlert, Enos Bernasconi, Roger D Kouyos, Huldrych F Günthard, Bruno Ledergerber, Jacques Fellay, Felix Burkhalter, Philip E Tarr, for the Swiss HIV Cohort Study, I Abela, K Aebi-Popp, A Anagnostopoulos, M Battegay, E Bernasconi, D L Braun, H C Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, H F Günthard, A Hachfeld, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, M Huber, D Jackson-Perry, C R Kahlert, L Kaiser, O Keiser, T Klimkait, R D Kouyos, H Kovari, K Kusejko, N Labhardt, K Leuzinger, B Martinez de Tejada, C Marzolini, K J Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, G Pantaleo, M Perreau, A Rauch, L Salazar-Vizcaya, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, M Weisser, S Yerly
Institutions: University of Basel, Kantonsspital Baselland, Kantonsspital Baselland Standort Bruderholz, Centre Hospitalier Universitaire Vaudois, École Polytechnique Fédérale de Lausanne, University of Lausanne, University of Bern, University Hospital of Bern, University of Copenhagen, Hvidovre Hospital, Rigshospitalet, Centre of Excellence for Health, Immunity and Infections, University of Zurich, University Hospital Zurich, University Hospital of Geneva, University Hospital of Basel, Kantonsspital St. Gallen, University of Geneva, Ospedale regionale di Lugano, Università della Svizzera italiana
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,536
OpenAlex ID: W4377941289