Functional and Clinical Importance of SGLT2-inhibitors in Frailty: From the Kidney to the Heart
Year: 2023
Type: article
Abstract: SGLT2 (sodium-glucose cotransporter 2) enables glucose and sodium reabsorption in the kidney. SGLT2-inhibitors (also known as gliflozins, which include canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin) act by increasing glycosuria, thereby reducing glycemia. These drugs are critical to reach and keep glycemic control, a crucial feature, especially in patients with comorbidities, like frail individuals. Several studies evaluated the effects of SGLT2-inhibitors in different settings beyond diabetes, revealing that they are actually pleiotropic drugs. We recently evidenced the favorable effects of SGLT2-inhibition on physical and cognitive impairment in frail older adults with diabetes and hypertension. In the present overview, we summarize the latest clinical and preclinical studies exploring the main effects of SGLT2-inhibitors on kidney and heart, emphasizing their potential beneficial actions in frailty.
Source: Hypertension
Authors: Gaetano Santulli, Fahimeh Varzideh, Imma Forzano, Scott Wilson, Luigi Salemme, Antonio de Donato, Angela Lombardi, Antonio Rainone, Luigi Nunziata, Stanislovas S. Jankauskas, Tullio Tesorio, Germano Guerra, Urna Kansakar, Pasquale Mone
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1000608447, G106075547, G1107707869, G1196682224, G1214234794, G1218068299, Molecular regulation of skeletal muscle thermogenesis, G1512127578, G1530010185, Inositol 1,4,5-trisphosphate receptors and activation of cardiac fibroblasts in ischemia/reperfusion injury, G180476886, G186995139, Beta Cell Intracellular Calcium and Diabetes, Functional role of IP3 receptors in the regulation of cardiac myofibroblasts, G2252929418, G2585684547, Modulation of Mitofusin Activity to Treat Heart Disease, G280444578, G281933567, G2836354684, G2940288175, G3074976661, Einstein-Montefiore Clinical and Translational Science Award Hub, G4073434654, Caspase-9 as a nodal point connecting necrotic and apoptotic cell death in myocardial infarction, Mechanisms of cardiovascular disease, G425922058, G4480573366, CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patients, G522617745, G5298350625, G531307636, G5423166509, G6133271709, G6237344070, G6295426566, G6505368759, G671159905, G6737277850, G7418095506, G7444043676, G7854002418, G790170206, G802470759, G8134671829, G8224181935, G8371146150, G8385843488, G8445767824, G8551577206, G8604045908, G8970445542, G9000020154, G9000036909, G9000045154, G9000045632, G9000148014, G9000203699, G9000239951, G9000291687, G981417163
OpenAlex ID: W4383186345