PB1070 Small and Large Extracellular Vesicles have Different Tissue Factor Activity in Cancer, Sepsis, and COVID-19
Year: 2023
Type: conference-abstract
Abstract: Methods: We performed a prospective single-centre study at Lausanne University Hospital (CHUV) including 294 non-anticoagulated patients with liver cirrhosis.The outcome was VTE including deep venous thrombosis, pulmonary embolism and SVT.We analysed in vivo TG-parameters ( prothrombin fragments 1 and 2 [F1+2], thrombin-antithrombin complexes [TAT], D-dimers) and ex vivo TG measured using the ST Genesia Thrombin Generation System (Stago, Asnieres-sur-Seine, France) with an intermediate concentration of tissue factor, without and with thrombomodulin (TM).Comparisons between groups were assessed by Mann-Whitney test.Results: Median age was 59 years (range, 18-81 years) and 68 patients (23%) were female.Regarding cirrhosis severity, 235 (79.9%) had a Child-Pugh score A, 49 (16.7%)B and 10 (3.4%) C. Comparisons between groups with and without VTE are presented in Table 1.The velocity index, TM-mediated inhibition, TAT, F1+2 and D-dimers as well as aPTT and PT were significantly associated with the VTE risk.Table.Data are number (%), respectively median (standard deviation) and results of Mann-Whitney tests.ETP, endogenous thrombin potential; TM, thrombomodulin; aPTT, activated partial thromboplastin time.
Authors: A. Sachetto, S. Archibald, Y. Hisada, A. Rosell, S. Havervall, N. van Es, R. Nieuwland, R. Campbell, E. Middleton, M. Rondina, C. Thålin, N. Mackman
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,250
OpenAlex ID: W4388597201