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Blood Cholesterol and Triglycerides Associate with Right Ventricular Function in Pulmonary Hypertension

Year: 2024

Type: preprint

Abstract: ABSTRACT Background Blood lipids are dysregulated in pulmonary hypertension (PH). Lower high-density lipoproteins cholesterol (HDL-C) and low-density lipoproteins cholesterol (LDL-C) are associated with disease severity and death in PH. Right ventricle (RV) dysfunction and failure are the major determinants of morbidity and mortality in PH. This study aims to test the hypothesis that dyslipidemia is associated with RV dysfunction in PH. Methods We enrolled healthy control subjects (n=12) and individuals with PH (n=30) (age: 18-65 years old). Clinical characteristics, echocardiogram, 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (PET) scan, blood lipids, including total cholesterol (TC), triglycerides (TG), lipoproteins (LDL-C and HDL-C), and N-terminal pro-B type Natriuretic Peptide (NT-proBNP) were determined. Results Individuals with PH had lower HDL-C [PH, 41±12; control, 56±16 mg/dL, p <0.01] and higher TG to HDL-C ratio [PH, 3.6±3.1; control, 2.2±2.2, p<0.01] as compared to controls. TC, TG, and LDL-C were similar between PH and controls. Lower TC and TG were associated with worse RV function measured by RV strain ( R =–0.43, p =0.02 and R= –0.37, p =0.05 respectively), RV fractional area change ( R =0.51, p <0.01 and R =0.48, p <0.01 respectively), RV end-systolic area ( R =–0.63, p <0.001 and R =–0.48, p <0.01 respectively), RV end-diastolic area: R =–0.58, p <0.001 and R =–0.41, p =0.03 respectively), and RV glucose uptake by PET ( R =–0.46, p =0.01 and R =–0.30, p =0.10 respectively). NT-proBNP was negatively correlated with TC ( R = – 0.61, p =0.01) and TG ( R =–0.62, p <0.02) in PH. Conclusion These findings confirm dyslipidemia is associated with worse right ventricular function in PH.

Source: medRxiv

DOI: 10.1101/2024.01.20.24301498