Year: 2024
Type: article
Abstract: Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.
DOI: 10.20517/jca.2023.50
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funders: American Heart Association, Diabetes Action Research and Education Foundation, European Commission, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1000608447, G1196682224, G1214234794, G1218068299, Molecular regulation of skeletal muscle thermogenesis, G1512127578, G1530010185, G180476886, G186995139, Beta Cell Intracellular Calcium and Diabetes, Functional role of IP3 receptors in the regulation of cardiac myofibroblasts, Modulation of Mitofusin Activity to Treat Heart Disease, G280444578, G281933567, G2836354684, G2940288175, G3074976661, Einstein-Montefiore Clinical and Translational Science Award Hub, Caspase-9 as a nodal point connecting necrotic and apoptotic cell death in myocardial infarction, Mechanisms of cardiovascular disease, G425922058, G4480573366, CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patients, G522617745, G5298350625, G531307636, G5423166509, G6295426566, G671159905, G6737277850, G7854002418, G790170206, G802470759, G8224181935, G8385843488, G8445767824, G9000020154, G9000036909, G9000045154, G9000045632, G9000148014, G9000203699, G9000291687, G981417163
OpenAlex ID: W4392741835