Direct Synthesis for Benzofuro[3,2‐d]pyrimidin‐2‐Amines via One‐Pot Cascade [4+2] Annulation/Aromatization between Benzofuran‐Derived Azadienes and Carbodiimide Anions
Year: 2024
Type: article
Abstract: The chemoselective [4+2] annulation/aromatization reactions between benzofuran-derived azadienes and N-Ts cyanamides are developed, affording a convenient method for synthesizing benzofuro[3,2-d]pyrimidin-2-amines under mild conditions. Herein, N-Ts cyanamides participated in reactions selectively via carbodiimide anion intermediates and the corresponding cyanamide anion intermediates derived products were not observed. The proposed chemoselective stepwise reaction mechanism was well supported by DFT calculations.
Source: Chemistry - A European Journal
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G3496166629
OpenAlex ID: W4402049700