Work

Additive‐Free and Diastereoselective Synthesis for Trans‐Disubstituted‐2,3‐Dihydro‐Benzofurans via [4+1] Annulation between p‐QMs and TFISYs

Year: 2024

Type: article

Abstract: An additive‐free and diastereoselective [4+1] annulation between ortho‐hydroxyphenyl‐substituted para‐quinone methides and CF3‐substituted imidoyl sulfoxonium ylides is developed, providing a facile and practical route to diverse trans‐2,3‐dihydrobenzofurans with high efficiency. This protocol features mild conditions, broad substrate scope and easy to operate.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400946

Authors: Yi‐Hui Li, Chuan‐Chuan Wang, Meng‐Ru Ren, Qing‐Long Wang, Ya‐Jing Chen

Institutions: Zhengzhou University, Henan University of Animal Husbandry and Economy

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Shanghai University of Traditional Chinese Medicine

Award: G3496166629