Work

Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study

Year: 2025

Type: article

Abstract: Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.

Source: Journal of Alzheimer s Disease

DOI: 10.1177/13872877251334820

Authors: Alison E Fohner, Colleen M Sitlani, Suman Jayadev, Joshua C Bis, Emily H Trittschuh, Oscar L Lopez, Russel P Tracy, Bruce M Psaty, WT Longstreth, Sudha Seshadri

Institutions: University of Washington, University of Pittsburgh, University of Vermont, The University of Texas at San Antonio Health Science Center

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute

Awards: G1002540797, G1220223050, G1261314546, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1396491130, CORONARY HEART DISEASE AND STROKE, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G2391884931, G247538147, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G3045517347, G3220743633, G3256118428, G3478977405, CHS research resources for the cardiovascular health of older adults, G3629610549, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Predictors of Alheimers Disease in Mild Cognitive Impairment, G5251985303, G5479317095, G581887176, CHS Events Follow-up Study, G6226795708, CHS-Transition Phase, G696863869, G7176672723, G8260701975, G9000037300, G9000071222, G9000114728, G9000171064, G9000180465, Integrated multi-omics approach to identify early protein biomarkers in Alzheimer's disease and cognitive decline, G926686101

OpenAlex ID: W4409722761

FWCI: 0.613

Cites: 41

Cited by: 1

Related to: 10