Work

Spatiotemporal calcium signaling patterns underlying opposing effects of histamine and TAS2R agonists in airway smooth muscle

Year: 2025

Type: article

Abstract: Using machine-learning methods, these studies identify spatiotemporal differences in calcium responses between agonists of Gq-coupled receptors and bitter taste receptors in airway smooth muscle cells. The findings provide deeper insights into the mechanism of action of bitter tastant-induced airway smooth muscle relaxation.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00058.2025

Authors: Stanley Conaway, Joshua Richard, Deepak A. Deshpande

Institution: Thomas Jefferson University

Language: English

Topic: Biochemical Analysis and Sensing Techniques

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

Open Access status: hybrid

Funder: National Heart, Lung, and Blood Institute