Year: 2025
Type: article
Study design: Observational Study
Abstract: This study aimed to determine whether daily low-dose aspirin reduces the risk of type 2 diabetes (T2D) associated with COVID-19. A longitudinal cohort of 200,000 adults followed from 2018 to 2022 was analyzed, comparing T2D incidence between aspirin users and non-users. Propensity score matching was used to balance the groups. The incidence of T2D was substantially lower in the aspirin group, with Cox regression showing a 52% risk reduction. Kaplan-Meier analysis confirmed a significant divergence in cumulative T2D risk after two years. This protective effect was observed both before and during the COVID-19 pandemic, with a stronger association during the pandemic period. These findings indicate that daily low-dose aspirin significantly reduces the risk of COVID-19-associated new-onset T2D, highlighting the role of inflammation in the pathogenesis of T2D triggered or unmasked by COVID-19.
Source: npj Metabolic Health and Disease
Authors: Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Maria Virginia Manzi, Stanislovas S. Jankauskas, Paola Gallo, Francesco Rozza, Giuseppe Giugliano, Alessandra Spinelli, Giovanni Esposito, Roberto Piccinocchi, Gaetano Piccinocchi, Carmine Morisco, Maria Lembo, Gaetano Santulli, Bruno Trimarco
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Awards: G1000608447, G1196682224, G1214234794, G1218068299, Molecular regulation of skeletal muscle thermogenesis, G1413706045, G1512127578, G1530010185, G186995139, Beta Cell Intracellular Calcium and Diabetes, Functional role of IP3 receptors in the regulation of cardiac myofibroblasts, G249311083, Modulation of Mitofusin Activity to Treat Heart Disease, G280444578, G281933567, G2836354684, G2940288175, A paradigm-shifting idea in storage-disease cardiomyopathy, G3074976661, G3672453180, Einstein-Montefiore Clinical and Translational Science Award Hub, Caspase-9 as a nodal point connecting necrotic and apoptotic cell death in myocardial infarction, Mechanisms of cardiovascular disease, G425922058, G4480573366, CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patients, G522617745, G5298350625, G531307636, G5423166509, G6295426566, G671159905, G6737277850, G7492960808, G7854002418, G790170206, G802470759, G8224181935, Purposeful Outreach for Diversity and Inclusion of Underrepresented in Medicine (PODIUM) Physician-Scientists, G8385843488, G8445767824, G864706750, G873634175, G8843290393, G9000020154, G9000036909, G9000045154, G9000045632, G9000148014, G9000203699, G9000291687, G981417163
OpenAlex ID: W4411424088