Changes in Body Mass Index in Children and Adolescents Living With Human Immunodeficiency Virus in Europe and Thailand Starting Dolutegravir
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Excess weight gain has been reported in some adults on dolutegravir (DTG), but data in children/adolescents living with human immunodeficiency virus (CALHIV) are limited. Methods CALHIV aged 2–17 years at DTG start from 15 observational cohorts across Europe and Thailand were included. Mixed models described changes in body-mass-index-for-age z-score (zBMI). We assessed (1) zBMI change 48 weeks before versus after DTG start; (2) zBMI change up to 96 weeks on DTG and associated factors; and (3) zBMI changes over 96 weeks in CALHIV aged 6–17 years at start of DTG versus protease inhibitor (PI)–based regimens using propensity score weighting. Results Of 948 CALHIV on DTG (>99% HIV-1, <1% HIV-2), 50% were female, the median age was 13.7 (interquartile range [IQR], 11.1–15.6]) years, median zBMI was 0.31 (IQR, −0.64 to 1.19), 48% were Black, and 30% were overweight or obese at DTG start. Among 741 participants with zBMI available before and after DTG start, zBMI (95% confidence interval (CI) increased by 0.07 (.03–.11) versus 0.13 (.09–.16) (P = .087), in the 48 weeks before and after DTG start, respectively. Mean zBMI change by 96 weeks on DTG was 0.20 (95% CI .14–.27). In multivariable models, greatest increases in zBMI were in those aged 6–11 years at DTG start (0.34 [95% CI .23–.44]), males of “other” ethnicity (0.39 [95% CI .10–.68]), Black females (0.27 [95% CI .15–.39]), and those on tenofovir alafenamide (TAF) (0.39 [95% CI .17–.61]). There was no difference in mean zBMI change at 96 weeks among those on DTG- versus PI-based regimens (0.21 [95% CI .13–.30] vs 0.30 [95% CI .13–.48]; P = .354). Conclusions CALHIV experienced zBMI increases on DTG with the largest gains in children aged 6–11 years, on TAF, with low baseline zBMI, and some variation by sex and ethnicity. However, zBMI changes over 96 weeks were comparable between those on DTG- and PI-based regimens.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofaf640
Authors: Elizabeth Chappell, Siobhan Crichton, Intira Jeannie Collins, Giorgia Dalla Valle, Charlotte Duff, Kate Edgar, Carlo Giaquinto, Charlotte Jackson, Ali Judd, Laura Mangiarini, John O’Rourke, Karen Scott, Claire Thorne, Tessa Goetghebuer, Marc Hainaut, Wivine Tremerie, Marc Delforge, Thomas Ulrik Hoffmann, Sannie Brit Nordly, Marla B Braun, Vana Spoulou, Luisa Galli, Elena Chiappini, Catiuscia Lisi, Carlotta Montagnani, Elisabetta Venturini, Magdalena Marczyńska, Jolanta Popielska, Maria Pokorska-Śpiewak, Agnieszka Ołdakowska, Konrad Zawadka, Magdalena Pluta, Małgorzata Doroba, Luminita Ene, María José Mellado, Luis Escosa, Milagros García-López Hortelano, Talía Sainz, Carlos Grasa, Paula Rodríguez, Jose Tomás Ramos, Pablo Rojo, Luis Prieto-Tato, Cristina Epalza, Alfredo Tagarro, Sara Domínguez, Álvaro Ballesteros, Marta Illán, Arantxa Berzosa, Sara Guillén, Beatriz Soto, María Luisa Navarro, Jesús Saavedra, Mar Santos, Elena Rincón, David Aguilera, Begoña Santiago, Beatriz Lázaro Martín, Andrea López Suárez, Amanda Bermejo, María Penín, Jorge Martínez, Katie Badillo, Ana Belén Jiménez, Adriana Navas, Eider Oñate, Itziar Pocheville, Elisa Garrote, Elena Colino, Olga Afonso, Jorge Gómez Sirvent, Mónica Garzón, Vicente Román, Raquel Angulo, Olaf Neth, Lola Falcón, Pedro Terol, Juan Luis Santos, Álvaro Vázquez, Begoña Carazo, Antonio Medina, Francisco Lendínez, Mercedes Ibáñez, Estrella Peromingo, María Isabel Sánchez, Beatriz Ruiz, Ana Grande, Francisco José Romero, Carlos Pérez, Alejandra Méndez, Laura Calle-Miguel, Virginia Courel del Río, Marta Pareja, Begoña Losada, Mercedes Herranz, Matilde Bustillo, Pilar Collado, José Antonio Couceiro, Leticia Vila, Consuelo Calviño, Ana Isabel Piqueras, Manuel Oltra, César Gavilán, Elena Montesinos, Marta Dapena, Beatriz Jiménez, Ana Gloria Andrés, Víctor Marugán, Carlos Ochoa, Ana Isabel Menasalvas, Eloísa Cervantes, Cristina Díez, Ignacio Bernardino, María Luisa Montes, Eulalia Valencia, Ana Delgado, Rafael Rubio, Federico Pulido, Otilia Bisbal, Alfonso Monereo Alonso, Juan Berenguer, Cristina Díez, Teresa Aldamiz, Francisco Tejerina, Juan Carlos Bernaldo de Quirós, Belén Padilla, Raquel Carrillo, Pedro Montilla, Elena Bermúdez, Maricela Valerio, Jose Sanz, Alejandra Gimeno, Miguel Cervero, Rafael Torres, Santiago Moreno, María Jesús Perez, Santos del Campo, Pablo Ryan, Jesus Troya, Jesus Sanz, Juan Losa, Rafael Gomez, Miguel Górgolas, Alberto Díaz, Sara de la Fuente, Jose Antonio Iribarren, Marıa Jose Aramburu, Lourdes Martinez, Ane Josune Goikoetxea, Sofia Ibarra, Mireia de la Peña, Víctor Asensi, Michele Hernandez, María Remedios Alemán, Ricardo Pelazas, María del Mar Alonso, Ana María López, Dácil García, Jehovana Rodriguez, Miguel Angel Cardenes, Manuel A Castaño, Francisco Orihuela, Inés Pérez, Mª Isabel Mayorga, Luis Fernando Lopez-Cortes, Cristina Roca, Silvia Llaves, Marıa Jose Rios, Jesus Rodriguez, Virginia Palomo, Juan Pasquau, Coral Garcia, Jose Hernandez, Clara Martinez, Antonio Rivero, Angela Camacho, Dolores Merino, Miguel Raffo, Laura Corpa, Elisa Martinez, Fernando Mateos, Jose Javier Blanch, Miguel Torralba, Piedad Arazo, Gloria Samperiz, Celia Miralles, Antonio Ocampo, Guille Pousada, Alvaro Mena, Marta Montero, Miguel Salavert, Maria Jose Galindo, Natalia Pretel, Joaquín Portilla, Irene Portilla, Felix Gutierrez, Mar Masia, Cati Robledano, Araceli Adsuar, Carmen Hinojosa, Begoña Monteagudo, Pablo Bachiller, Jesica Abadía, Carlos Galera, Helena Albendin, Marian Fernandez, Jose Ramon Blanco, Pere Soler-Palacín, Maria Antoinette Frick, Santiago Pérez-Hoyos, Núria López, María Méndez, Clara Carreras, Borja Guarch-Ibáñez, Teresa Vallmanya, Laura Minguell-Domingo, Olga Calavia, Lourdes García, Maite Coll, Valentí Pineda, Neus Rius, Núria Rovira, Joaquín Dueñas, Clàudia Fortuny, Anna Gamell, Antoni Noguera-Julian, Lars Navér, Nora Einarsson, Vendela Hagås, Johanna Rubin, Sandra Soeria-Atmadja, Irene Alma Abela, Karoline Aebi-Popp, Alexia Anagnostopoulos, Manuel Battegay, Marc Baumann, Enos Bernasconi, Dominique Laurent Braun, Heiner C Bucher, Alexandra Calmy, Matthias Cavassini, Angela Ciuffi, Pierre-Alex Crisinel, Katharine E A Darling, Günter Dollenmaier, Andrea Duppenthaler, Matthias Egger, Luisa Elzi, Jan Sven Fehr, Jacques Fellay, Katyuska Francini, Hansjakob Furrer, Christoph Andreas Fux, Huldrych Fritz Günthard, Anna Hachfeld, David Hans-Ulrich Haerry, Barbara Hasse, Hans Hellmuth Hirsch, Matthias Hoffmann, Irene Hösli, Michael Huber, David Jackson-Perry, Christian R Kahlert, Olivia Keiser, Thomas Klimkait, Malte Kohns, Lisa Kottanattu, Roger Dimitri Kouyos, Helen Kovari, Katharina Kusejko, Niklaus Daniel Labhardt, Karoline Leuzinger, Begoña Martinez de Tejada, Catja Marzolini, Karin Jutta Metzner, Nicolas Müller, Johannes Nemeth, Dunja Nicca, Julia Notter, Paolo Paioni, Giuseppe Pantaleo, Matthieu Perreau, Christian Polli, Elisabetta Ranieri, Andri Rauch, Luisa Paola Salazar-Vizcaya, Patrick Schmid, Olivier Segeral, Roberto F Speck, Marcel Stöckle, Philip Edward Tarr, Lecompte Marthe Than, Alexandra Trkola, Noémie Wagner, Gilles Wandeler, Maja Weisser, Sabine Yerly, Rachaneekorn Nadsasarn, Chutima Saisaengjan, Patama Deeklum, Phattharapa Khamkhen, Lucksanapon Pitikawinwong, Nattakarn Tantawarak, Pope Kosalaraksa, Chanasda Kakkaew, Tetiana Kaleeva, Yulia Baryshnikova, Iryna Raus, Olena Glutshenko, Halyna Sherstiuk, Iryna Shkurka, Natalia Delikhovska, Iryna Popova, Tetiana Golubieva, Alla Volokha, Ruslan Malyuta, Claire Thorne
Institution: University College London
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,053
Award: Swiss HIV Cohort Study
OpenAlex ID: W4415062062