Figure 2 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Year: 2025
Type: other
Abstract: Effects of velcrin treatment on leukemic progenitor colony formation. A and B, Clonogenic capability of HEL (A) or U937 (B) cells following treatment with increasing concentrations of BAY 2666605, as noted, for 1 week. Leukemic colony formation (CFU-L) was calculated as percent colony formation relative to vehicle control (DMSO)–treated cells (indicated by the dotted line) and means ± SEM of (A) three or (B) five independent experiments are presented. Each dot represents an independent experiment. At each concentration, statistical significance was determined using a one-sample Student t test compared with 100%; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001. C, Effects on primary AML-derived leukemic progenitor colony formation. Cells were plated in a methylcellulose culture assay system and treated the same day with BAY 2666605 at the noted concentrations. Leukemic colony formation (CFU-L) was calculated as percent colony formation of BAY 2666605–treated patient samples (2 weeks) relative to vehicle control (DMSO)–treated cells (indicated by the dotted line). Each dot represents an independent experiment. Data are shown as means ± SEM of five independent experiments, as indicated, using primary cells from five different patients with AML. At each concentration, statistical significance was determined using a one-sample Student t test compared with 100%; ***, P ≤ 0.001; ****, P ≤ 0.0001. BAY, BAY 2666605.
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4416300038
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