Work

Biomimetic Total Synthesis of Dispirocochlearoids A–C and Related Ganoderma Meroterpenoid Dimers

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The first total synthesis of the anti-inflammatory Ganoderma meroterpenoid dimers dispirocochlearoids A–C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that leveraged common intermediates derived from dayaolingzhiol M. The synthesis features several key steps: a hetero-Diels–Alder reaction, a hydrolysis/double-bond migration cascade to assemble the D/E–bicyclic core, and a condensation/intramolecular aldol/lactonization cascade that constructs the final B/C–bicyclic system of dispirocochlearoids A–C.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c04234