Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells
Year: 2026
Type: preprint
Abstract: ABSTRACT CD4 + T cells that produce IFN-γ (T helper 1 [Th1] cells) chiefly mediate vaccine acquired resistance to fungal infections. However, the key regulators of the development of Th1 cells and acquired resistance to fungi are incompletely understood. Here, we report that Natural Killer Cell Granule Protein (NKG7) acts as an unappreciated regulator inducing anti-fungal Th1 cells to produce IFN-γ and converting plastic Th17 cells into polyfunctional memory Th1 cells. Author summary The mechanisms of vaccine resistance to fungi are incompletely understood. We identified a regulator that promotes the development of proinflammatory immune lymphocytes and fosters the conversion of one population of lymphocytes into multi-functional cells that produce several proinflammatory soluble factors that efficiently combat infectious diseases.
Authors: Marcel Wüthrich, Cleison Ledesma Taira, Lucas dos Santos Dias, Xin He, Sarah Lichtenberger, Bruce S. Klein
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Regulation of vaccine-induced anti-fungal Th17 cells, Special BD LSR Fortessa, Mechanisms of anti-fungal Vaccine immunity, Combination Adjuvants to Program Durable Immunity to Respiratory Viral and Fungal Pathogens, Mechanisms of vaccine immunity against coccidioidomycosis, Molecular pathogenesis of blastomycosis, UW Comprehensive Cancer Center Support, Fungal Antigen Resources for Development of Vaccines and Diagnostics
OpenAlex ID: W7155356102