Work

Principles for the design of multispecific proteins

Year: 2026

Type: article

Abstract: Multispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid core recognising conserved features of all targets, with flexible peripheral regions enabling discrimination within the target family.

Source: Trends in Biochemical Sciences

DOI: 10.1016/j.tibs.2026.04.007

Authors: Shankar Raj Devkota, Pramod Aryal, Mikaela Bell, Surendra Kunwar, Martin J. Stone, Ram Prasad Bhusal

Institutions: Adelaide University, Monash University, The University of Adelaide

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funder: National Health and Medical Research Council