Dynamics of airway macrophage responses and lung function changes after ozone exposure in humans
Year: 2026
Type: article
Study design: Clinical Trial
Abstract: Macrophage involvement in the human response to ozone remains poorly defined. In this human crossover exposure study, we characterized ozone-induced changes in airway macrophage populations at 24, 48, and 72 h post-exposure. Ozone exposure caused immediate declines in pulmonary function, which improved 24-72 h later; recovery was associated with increases in airway monocyte-derived macrophage-to-neutrophil and monocyte-derived macrophage-to-monocyte ratios. These findings highlight coordinated, time-related macrophage dynamics that may contribute to recovery from ozone-induced lung injury.
Institution: Rutgers, The State University of New Jersey
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W7214377140